About the Lab
The long-term research goal of the Sirota Lab is to develop integrative computational methods and apply these approaches in the context of disease diagnostics and therapeutics with a focus on women's health. We study reproductive health and conditions such as endometriosis as well as adverse pregnancy outcomes such as preterm birth and recurrent pregnancy loss. We also explore conditions that disproportionally affect women such as autoimmunity and neurodegeneration. We are specifically interested in leveraging and integrating different types of omics and clinical data to better understand the role of the immune system in disease. The laboratory is funded by several National Institutes of Health including NIA, NLM, NIAMS, NICHD, Pfizer, March of Dimes and the Burroughs Wellcome Fund.
The Sirota Lab is part of the Department of Pediatrics and the Bakar Computational Health Sciences Institute at UCSF.
We are located in UCSF Mission Bay at 490 Illinois St, Floor 2, San Francisco, CA.
News
Data Science in Drug Discovery | Wrangle Conference
UCSF Alumni Week 2020: Your Microbial Universe - Using Microbes as Medicine
Carry the One Radio: Women in Data Science - Dr. Marina Sirota
Carry the One Radio: Teaching Old Drugs New Tricks
Integrating Clinical and Molecular in the Era of Precision Medicine
Drug Discovery in the Era of Precision Medicine
UCSF Department of Medicine Grand Rounds: The Science Behind Real-World Data - Answering Today’s Questions Today
MELODEM Working Group: Leveraging Molecular and Clinical Data to Better Understand Alzheimer's Disease
Research
Computational Integrative Methods for Reproductive Health
Each year, 15 million babies (representing 10% of the world's births) are born preterm, defined as before the 37th week of gestation. Survival for most children born preterm has improved considerably, but surviving children remain at increased risk for a variety of serious complications, many of which contribute to lifelong challenges for individuals and their families, as well as to burdensome economic costs to society. The exact mechanism of spontaneous preterm birth is unknown, though a variety of social, environmental, and maternal factors have been implicated in its cause. We are in particular interested in applying computational integrative methods to investigate the role of the immune system in pregnancy (J Immunology 2021) and elucidating genetic (Sci Rep 2018), transcriptomic (Front Immunol 2018), microbiome (Front Microbio 2020, Cell Reports Medicine 2023), environmental (Environ Health 2018, Environ Int 2018, Environ Sci Technol 2021), and clinical (BMC Med 2022, Sci Transl Med 2023, npj Womens Health 2024) determinants of preterm birth. We are leading some drug discovery efforts in this space as well (JCI Insight 2020). Moreover, through the March of Dimes (MOD) Database for Preterm Birth Research, we are leading efforts to organize scientific data and research across all MOD-funded Prematurity Research Centers with the goal of enhancing research collaboration and coordination to accelerate the overall pace of discovery in this field (Sci Data 2018). In addition, we are investigating other relevant conditions such as endometriosis (ENACT) and adverse outcomes such as recurrent pregnancy loss (TRIOS) from the molecular and clinical perspectives. This work is funded by the by the NLM and NICHD at the NIH, March of Dimes and The Burroughs Wellcome Fund.
Computational Approaches to Inform Therapeutics of Alzheimer's Disease and Related Dementias (ADRD)
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder caused by interactions among multiple genetic and environmental factors. Apolipoprotein (APO) E4 has been identified as the major genetic risk factor for AD. It increases the risk and lowers the age of onset of AD in a gene dose–dependent manner. The genetic complexity and multifactorial nature of AD pose unique challenges for developing effective therapies and suggest the need of a precision medicine approach that takes into account individual variability. We have been developing and applying an multi-omics integrative approach leveraging publicly available human genomics and transcriptomics to elucidate sex-specific (Mol Neurobiol 2021) and apoE genotype-specific (Frontiers in Aging Neuroscience 2022) molecular pathways involved in AD with a focus towards neuroinflammation. We are further interested in seeing how these differences impact diagnostics and therapeutics (Trends Pharmacol Sci 2019, Nature Aging 2021, Research Square 2024). Finally, we have been leveraging clinical data to better understand disease heterogeneity in AD with a focus on exploring sex differences (Nat Commun 2022, Commun Med 2023) and applying predictive modeling approaches to identify which patients are more likely to develop AD (Nature Aging 2024). This work has been funded by NIA at NIH.
Integrative Genomics for Autoimmune Disease
With the advent of genotyping and whole genome sequencing technologies, more and more omics data is becoming available for integrative analysis and provides an opportunity to ask new questions about disease. We are interested in leveraging the genetic data across phenotypes to elucidate the genetic architecture of disease with a special interest in autoimmune diseases (Plos Genetics 2009). Furthermore we are interested in leveraging and applying next-generation sequencing technologies in order to better understand the role of the immune system in disease (JCI 2012, STM 2014). We have on-going projects in Systemic Lupus Erythematosus (SLE) (Nat Comms 2019, Comms Bio 2021), Rheumatoid Arthritis (RA) (Frontiers in Immunology 2021), and Dermatomyositis (ACR Open Rheum 2019). This work is currently funded by National Institute of Arthritis and Musculoskeletal and Skin Diseases at NIH and Pfizer.
Cancer Informatics
We are interested in using publicly available gene expression and genetics data to identify novel biomarkers and therapeutic strategies for cancer. We are actively working on developing computational approaches for target identification, therapeutic prediction and selection of validation models (CPT 2015, BMC Med Genomics 2015, PSB 2015). We have a special interest in studying the tumor microenvironment and the interaction of immune cells in the context of cancer (Nat Comms 2015) as well as evaluating cell lines as cancer models (Nat Comms 2019).
Computational Drug Discovery
The identification of novel disease indications for approved drugs, or drug repositioning, offers several advantages over traditional drug development. The traditional paradigm of drug discovery is generally regarded as protracted and costly, with studies showing that it takes approximately 15 years and over $1 billion to develop and bring a novel drug to market. The repositioning of drugs already approved for human use mitigates the costs and risks associated with early stages of drug development, and offers shorter routes to approval for therapeutic indications. We are interested in leveraging publicly available data to carry out data-driven computational drug repositioning. This methodology has been applied successfully to Crohn's disease and IBD (STM 2011, STM 2011), dermatomyositis (JID 2016), liver cancer (Nat Comms 2017), preterm birth (JCI Insight 2020), and most recently COVID-19 (JAMA Network Open 2021, Frontiers in Medicine 2021, Sci Rep 2021, PLoS Comput Biol 2023) as well as endometriosis (iScience 2024). This work has been funded by the NIA and NICHD at NIH.
People
Marina Sirota, PhD
Principal Investigator
Marina is currently a Professor and Acting Director of the Bakar Computational Health Sciences Institute at UCSF. Her research interests lie in developing computational integrative methods and applying these approaches in the context of disease diagnostics and therapeutics.
Jessica Neely, MD
Assistant Professor
Jessica is an Assistant Professor of Pediatrics who earned her MD from the University of Kentucky, and completed her Pediatric Residency and Rheumatology Fellowship at UCSF. Her primary research interest is in precision medicine approaches to care, with a specific focus on Juvenile Dermatomyositis.
Tomiko Oskotsky, MD
Associate Professor
Tomiko earned a BS in Biochemistry from UCLA and an MD from the Medical College of Wisconsin. Her research interests encompass the analysis of electronic health records and investigation of drug repositioning candidates.
Alice Tang, PhD
Postdoctoral Fellow
Alice is an MSTP Candidate who is currently an MD Student at UCSF. She earned her BS in Bioengineering from UCLA and PhD in Bioengineering from UC Berkeley. She loves collecting and working with data, from omics to sensor data and so on, with the goal of using data to understand human diseases.
Sarah Woldemariam, PhD
Postdoctoral Scholar
Sarah earned a BS in Chemistry from Case Western Reserve University and a PhD in Chemistry and Chemical Biology from UCSF. She is interested in leveraging computational tools and approaches to study Alzheimer's Disease and other heterogeneous diseases of the brain.
Monica Yang, MD
Assistant Professor
Monica is an Assistant Professor of Rheumatology at UCSF. She earned her MD & completed her Internal Medicine Residency at Northwestern University. She is interested in utilizing transcriptomic approaches to better define disease heterogeneity & phenotypic diversity in autoimmune disease, particularly in Systemic Sclerosis.
Silvia Miramontes, BA, MIDS
Bioinformatics Graduate Student
Silvia earned her BA in Applied Math and Master's of Information & Data Science from UC Berkeley. She previously worked in computer vision for applications in cancer and Alzheimer's Disease (AD). She is interested in developing a prediction model to explore how non-clinical features affect patients' risk of AD.
Laura Almonte, BS
Bioinformatics Graduate Student
Laura graduated from the National Autonomous University of Mexico with a BS in Genomic Sciences. They are interested in developing tools for data integration with an emphasis on autoimmune disease. Outside of lab, Laura is a bird enthusiast and an avid patron of museums and local drag queen shows.
Umair Khan, BS
Bioinformatics Graduate Student
Umair graduated from Portland State University with a BS in Computer Science and Mathematics. He is interested in developing novel computational approaches to better understand disease, broadly construed. (Co-advised with Michael Keiser.).
Ernest Lee, MD PhD
Assistant Professor
Ernest is a dermatologist and physician-scientist with a BS in Physics from Caltech and MD/PhD in Bioengineering from UCLA. His primary research interests lie in combining structural and data-driven approaches to engineer novel therapies for autoimmune and inflammatory skin diseases, with a focus on precision medicine in dermatology.
Ophelia Yin, MD
Clinical Fellow
Ophelia is a clinical fellow in Maternal-Fetal Medicine at UCSF. She completed her MD at Johns Hopkins and her residency in Ob/Gyn at UCLA. She is interested in utilizing transcriptomic approaches to understand the immunologic contributions to placentation disorders in pregnancy, including placenta accreta and preeclampsia.
Leen Arnaout, BS
Bioengineering Graduate Student
Leen graduated from Boston University with a BS in biomedical engineering. She is interested in integrating EHR and multi-omics data to predict the impact of autoimmunity on preterm birth incidence. Outside of lab, she enjoys bouldering, gardening and exploring Bay Area coffeeshops.
Carlota Pereda Serras, MS
PSPG Graduate Student
Carlota is interested in disease mechanisms of neurodegenerative diseases. Prior to UCSF, she worked on small molecule drug screening and iPSC-derived neuronal disease modeling. Carlota has a master's in Biomedical Engineering from Columbia University and a bachelor's degree in Biology from Brown University.
Brendan Mitchell, BS
Bioengineering Graduate Student
Brendan is a PhD Student at UC Berkeley and UCSF, co-advised by Duygu Tosun, PhD. He earned his BS in Neuroscience from UCR. He is interested in integrating longitudinal multi-omics and imaging data to better understand aging and brain disorders.
Claire Dubin, BA
Bioinformatics Graduate Student
Claire graduated from UC Berkeley with BAs in Microbiology and Data Science. She previously studied fungal evolution and population genetics. She is interested in using shotgun metagenomics data to understand how the microbiome influences pregnancy outcomes.
Bahar Yilmaz, MD
Clinical Fellow
Bahar is a clinical fellow in Reproductive Endocrinology and Infertility at UCSF. She earned her MD from Koç University in Istanbul and completed her OB/GYN residency at Northwestern University. Her research focuses on improving fertility treatments and identifying new therapies for uterine factor infertility.
Brenda Ametepe, BS
Bioengineering Graduate Student
Brenda is a PhD student at UCSF & UC Berkeley, co-advised by Dr. Minnie Sarwal. She earned her BS in Bioengineering at CSULB. Her research focuses on RNASeq data analysis for drug repurposing in organ transplants, translating discoveries into real-world solutions using computational tools.
Jessica Gelfand, BS
Physical Therapy Student/ Research Lab Assistant
Jessica earned her BS in Kinesiology at Arizona State University and is currently in the UCSF/SFSU Doctor of Physical Therapy program. In her free time, she enjoys going to the beach and exploring San Francisco.
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Xinyu (Cynthia) Tang, PhD
Postdoctoral Scholar
Xinyu earned her PhD degree in Nutritional Biology from UC Davis. She is interested in leveraging computational and multi-omics approaches to study the risk factors and therapeutic strategies for Alzheimer's Disease.
Alumni
- Romina Appierdo, MS Visiting Scholar (University of Rome Tor Vergata)
- Zainab Apalara, MPS ,Medical Student
- Yukari Katsuhara, PhD, Health Data Science Graduate Student
- Yaqiao Li, PhD, Research Scientist
- Zach Cutts, PhD, Bioinformatics Graduate Student
- Jean Costello, PhD, Postdoctoral Scholar (Postdoctoral Scholar, Boston University)
- Alice Tang, PhD, Bioengineering Graduate Student (Medical Student, UCSF)
- Simran Kanal, BS, Health Data Science Graduate Student
- Jason Akram, Stanford Undergraduate Student
- Lay Kodama, MD, PhD, Postdoctoral Fellow (Resident Physician of Psychiatry, University of California San Diego)
- Garret Bland, PhD, Postdoctoral Scholar (Data Scientist, Amunix)
- Wendy Su, UCLA Undergraduate Student (Graduate Student, University of Pennsylvania)
- Vienna Huang, UC Berkeley Undergraduate Student
- Adi Siddharth, Bioinformatics Programmer / Research Associate (Graduate Student, Johns Hopkins University)
- Alennie Roldan, Bioinformatics Programmer / Research Associate (Medical Student, Burrell College of Osteopathic Medicine)
- Brian Le, PhD, Postdoctoral Scholar (Computational Biologist, Inflammatix)
- Isha Karim, High School Student, Saint Francis High School
- Grace Yang, High School Student, Dougherty Valley High School
- Silvia Pineda, PhD, Postdoctoral Scholar (Assistant Professor in Statistical and Data Science, Universidad Complutense de Madrid)
- Dmitry Rychkov, PhD, Postdoctoral Scholar (Scientist II, Engine Biosciences)
- Stella Belonwu, PhD, PSPG Graduate Student (Science Communications Intern, Genentech)
- Katharine Yu, PhD, BMS Graduate Student (Bioinformatics Scientist, Atreca)
- Daniel Pique, PhD, Postdoctoral Scholar / Pediatrics Resident (Medical Genetics Resident, University of Colorado)
- Gaia Andreoletti, PhD, Postdoctoral Scholar (Bioinformatics Scientist, Audentes Therapeutics)
- Idit Kosti, PhD, Postdoctoral Scholar (Computational Biologist, Alkahest)
- Daniel Bunis, PhD, BMS Graduate Student (Senior Research Scientist, UCSF)
- Arohee Bhoja, High School Student, The Harker School
- Sachi Parikh, High School Student, Lynbrook High School
- Tia Jain, High School Student, Saratoga High School
- Christine Li, High School Student, Shanghai American School
- Roman Kouznetsov, UCLA Undergraduate Student
- Raghav Ganesh, High School Student, Lynbrook High School
- Aarzu Gupta, High School Student, The Harker School
- Irene Yang, High School Student, Dougherty Valley High School
- Manish Paranjpe, Research Associate, UCSF (Medical Student, Harvard University)
- Hongtai Huang, Postdoctoral Scholar, UCSF (Analyst II, Genentech)
- Fawwad Khan, Research Associate, UCSF (Medical Student, UT Southwestern)
- Alice Taubes, PhD, BMS Graduate Student, UCSF (Project Manager, Benevolent AI)
- Shan Andrews, Postdoctoral Scholar, UCSF (Computational Biologist at Denali Therapeutics)
- Aolin Wang, Postdoctoral Scholar, UCSF (Associate, Analysis Group)
- Ishan Paranjpe, Research Associate, UCSF (Medical Student, Mt. Sinai)
- Arabdha Biswas, High School Student, The Harker School (UC Santa Cruz Undergraduate)
- Akshay Ravoor, High School Student, The Harker School (UC Berkeley Undergraduate)
- Carolyn Wang, High School Student, Gunn High School (Columbia University Undergraduate)
- Labanya Mukhopadhyay, High School Student, Evergreen Valley High School (UC Berkeley Undergraduate)
- Anooshree Sengupta, High School Student, The Harker School (Stanford Undergraduate)
- Grace Cho, BS, Stanford Medical Student (Dermatology Resident, Stanford)
- Cindy Lin, Stanford Undergradaute Student (Software Engineer, Google)
- Nishant Jain, Yale Undergraduate Student (Software Engineer, Google)
- Charles Pei, High School Student (Harvard University Undergraduate)
Visiting Scholars
- Camilla Wibrand, PhD: Aug 2022 - May 2023 (Denmark)
- Antonio Leo Parraga, PhD: Aug 2022 - Dec 2022 (Spain)
- Karolin Froelich, PhD: Apr 2019 - Sept 2019 (Germany)
- Isam Ben Soltane: Apr 2019 - Aug 2019 (France)
- Ramy Karam Aziz: Aug 2018 (Egypt)
Rotation Students
- Kira Buttrey, BMI
- Cindy Barrios, BMI
- Umair Khan, BMI
- Grace Ramey, BMI
- Ana Laura Almonte, BMI
- Jay Liu, BMI
- Sebastián Cruz González, BMI
- Silvia Miramontes, BMI
- Susanna Morin, BMI
- Parker Grosjean, BMI
- Harry Sun, BMS
- Cuyler Luck, BMS
- Maggie Tsui, BMI
- Pooja Kathail, Computational Biology (Berkeley)
- Ketrin Gjoni, PSPG
- Brenda Miao, BMI
- Jackie Roger, BMI
- Caroline Warly Solsberg, PSPG
- Whitney Tamaki, PSPG
- Emily Connelly, PSPG
- Michelle Wang, PSPG
- Kirsten Chen, BMS
- Bianca Vora, PSPG
- Kennedy Agwamba, Computational Biology (Berkeley)
Close Collaborators
- Atul Butte, MD, PhD (Institute for Computational Health Sciences, UCSF)
- Dexter Hadley, MD, PhD (Institute for Computational Health Sciences, UCSF)
- Bin Chen, PhD (Institute for Computational Health Sciences, UCSF)
- Dvir Aran, PhD (Institute for Computational Health Sciences, UCSF)
- Hanna Paik, PhD (Institute for Computational Health Sciences, UCSF)
- Nadav Rappoport, PhD (Institute for Computational Health Sciences, UCSF)
- David Stevenson, MD, Gary Shaw, PhD, Nima Aghaeepour, PhD, Brice Gaudilliere, MD PhD (Stanford MOD Prematurity Center, Stanford University)
- David Relman, PhD, Steven Quake, PhD, Martin Angst, MD (Stanford MOD Prematurity Center, Stanford University)
- Laura Jelliffe-Pawlowski, PhD, Larry Rand, MD (Preterm Birth Initiative, UCSF)
- Tippi McKenzie, MD, PhD (Fetal Maternal Medicine, UCSF)
- Linda Guidice, MD, PhD (Obstetrics, Gynecology and Reproductive Sciences, UCSF)
- Minnie Sarwal, MD, PhD (Nephrology, UCSF)
- Tracey Woodruff, PhD (Environmental Science, UCSF)
- Jinoos Yazdany, MD (Rheumatology, UCSF)
- Lindsey Criswell, MD, MPH (Rheumatology, UCSF)
- Esteban Burchard, MD, MPH (Pulmonology, UCSF)
- Steven Finkbeiner, MD, PhD (Neurology, Gladstone/UCSF)
- Yadong Huang, MD, PhD (Neurology, Gladstone/UCSF)
- Christian von Buedingen, MD (Neurology, UCSF)
- Steven Bagley, PhD and Russ Altman, MD, PhD (Biomedical Informatics, Stanford University)
- Cristina Lanata, MD (Rheumatology, UCSF)
- Chaz Langelier, MD, PhD (Infectious Diseases, UCSF)
- Kathy Giacomini, PhD (Bioengineering, UCSF)
- Benjamin Glicksberg, PhD (Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai)
- Jennifer Yokoyama, PhD (Memory and Aging Center, UCSF)
- Jonathan Golob, MD, PhD (Infectious Diseases, University of Michigan)
Teaching
Spring 2017-2020 | Computational Immunology Mini Course
This course provides an overview of computational methods used in the analysis of immunological data, including transcriptomics, next generation sequencing, cytometry and CyTOF. We provide a theoretical framework but focus on real applications.
The first hour of each session is in lecture format (livestreamed and archived) followed by an intimate disucssion session with the registered students.
- Spring 2020 (COVID-19 focus): Co-directed by Gabi Fragiadakis and Matt Spitzer.
- Spring 2019: Co-directed by Jill Hollenbach and Matt Spitzer.
- Spring 2018: Co-directed by Jill Hollenbach and Matt Spitzer
- Spring 2017: Co-directed by Matt Spitzer.
Summer 2016 | Computational Immunology Seminars
A Computational Immunology Seminar Series offered in collaboration with Stanford University. Seminars hosted at Stanford and interactively streamed at UCSF in Mission Hall. Subscribe to updates about lectures.
Open Positions
Post-doctoral opportunities in Translational Bioinformatics at UCSF
The laboratory of Dr. Marina Sirota at UCSF is seeking highly motivated investigators to develop and study novel approaches in translational bioinformatics, or the application of analytic and interpretive methods to optimize the transformation of genomic and clinical data into precision medicine. We are currently recruiting investigators interested in focusing on using omics and integrative approaches to study pregnancy outcomes with a focus on preterm birth.
Ideal candidates will have an M.D. and/or Ph.D. with a strong background in bioinformatics, computational biology, biostatistics, and genomics, and a great publication record.
Strong problem-solving skills, creative thinking, and the ability to build new software tools as needed are required. Applicants must possess good communication skills and be fluent in both spoken and written English. A background in molecular biology or medicine or pharmacology will be a strong plus. Prior experience with genetic, microarray, drug, or clinical databases, text-mining, knowledge representation, or parallel computing platforms is a plus. This exciting work will be guided by multidisciplinary collaborations with top scientists in neonatology, genetics, environmental science, immunology and microbiome research at UCSF.
To apply, please send your CV, a brief statement of research interests, and contact information for three references in one PDF document to marina.sirota@ucsf.edu.
Rotation Students
The Sirota Lab has openings each quarter for rotating students.
Expecations:
- You will be expected to spend close to the theoretical 50% working in the lab, and spend that 50% in our office-space in Mission Hall.
- You will meet with the PI on a bi-weekly basis.
- You will need to interact with the Post-doctoral Fellows and graduate students.
- You are expected to attend the weekly laboratory meetings.
- You will be expected to present to the laboratory in the presentation rotation.
What you will learn:
High School Students
We strongly recommend you apply through the UCSF high school research summer program . Exceptional applicants outside this program will be considered.
College Students
We accept students through the UCSF Summer Internship Program. Exceptional candidates outside the program will be considered, especially if the applicants have fellowship funding and a track-record of publications in biomedical informatics.
Pre-Prints
Sarwal R, Tarca V, Kalavros N, Bhatti G, Bhattacharya A, Butte AJ, Romero RJ, Stolovitzky G, Oskotsky TT, Tarca AL, Sirota M. Benchmarking Large Language Models for Predictive Modeling in Biomedical Research With a Focus on Reproductive Health. bioRxiv 2025. 10.1101/2025.07.07.663529Oskotsky TT, Tang X, Arthurs E, Govil A, Abbasi F, Bhoja A, Bunis DJ, Lau A, Einhaus J, Diop M, Irwin JC, Gaudilliere B, Stevenson DK, Giudice LC, McAllister SL, Sirota M. A Transcriptomics-Based Computational Drug Repositioning Pipeline Identifies Simvastatin And Primaquine As Novel Therapeutics For Endometriosis Pain. bioRxiv 2025. 10.1101/2025.05.28.656743
Tang A, Wei M, Haemel A, La C, Sirota M, Lee EY. Artificial intelligence-enabled precision medicine for inflammatory skin diseases. arXiv 2025. 10.48550/arXiv.2505.09527
Yin O, Almonte-Loya A, Appierdo R, Yang M, Yilmaz BD, T Oskotsky TT, M Gonzalez JM, C Giudice LC, Afshar Y, Sirota M. Transcriptomic comparison of early onset preeclampsia and placenta accreta identifies inverse trophoblast and decidua functions at the maternal-fetal interface. bioRxiv 2025. 10.1101/2025.05.09.653201
Lee EY, Patterson S, Cutts Z, Lanata CM, Dall'Era M, Yazdany J, Criswell LA, Haemel A, Katz P, Ye CJ, Langelier C, Sirota M. Transcriptomic analysis reveals immune signatures associated with specific cutaneous manifestations of lupus in systemic lupus erythematosus. bioRxiv 2025. 10.1101/2025.04.27.649460
Katsuhara Y, Khan U, Miller ZA, Allen IE, Oskotsky TT, Sirota M, Tang AS. Decoding subphenotypes in electronic medical records within late-onset Alzheimer's disease reveals heterogeneity and sex-specific differences. medRxiv 2025. 10.1101/2025.04.24.25326306
Papenberg M, Wang C, Diop M, Bukhari SH, Oskotsky B, Davidson BR, Vo KC, Liu B, Irwin JC, Combes A, Gaudilliere B, Li J, Stevenson DK, Klau GW, Giudice LC, Sirota M, Oskotsky TT. Anticlustering for Sample Allocation To Minimize Batch Effects. bioRxiv 2025. 10.1101/2025.03.03.641320
Paik H, Ko TL, Sirota M, Park J, Bunis D, Lee S, Heo H. Searching for influencers among placental immune cells in preeclampsia. bioRxiv 2025. 10.1101/2025.03.04.641363
LaHue SC, Takegami N, Simmasalam R, Baqai A, Munoz E, Sikri A, Courson T, Singhal NS, Eckalbar W, Langelier CR, Hendrickson CM, Calfee CS, Erle DJ, Krummel MF, Woodruff PG, Oskotsky T, Sirota M, Ferguson A, Douglas VC, Newman JC, Pleasure SJ, Wilson MR, Singhal NS. Peripheral blood mononuclear cell transcriptomic trajectories reveal dynamic regulation of inflammatory actors in delirium. medRxiv 2025. 10.1101/2025.02.14.25322163
Khan U, Oskotsky TT, Yilmaz BD, Roger J, Gjoni K, Irwin JC, Opoku-Anane J, Elhadad N, Giudice LC, Sirota M. Comorbidity analysis and clustering of endometriosis patients using electronic health records. medRxiv 2025. 10.1101/2025.02.13.25322244
Li Y, Serras CP, Blumenfeld J, Xie M, Hao Y, Deng E, Chun YY, Holtzman J, An A, Yoon SY, Tang X, Rao A, Woldemariam S, Tang A, Zhang A, Simms J, Lo I, Oskotsky TT, Keiser MJ, Huang Y, Sirota M. Data-driven discovery of cell-type-directed network-correcting combination therapy for Alzheimer's disease. bioRxiv. 2024. 10.1101/2024.12.09.627436
Woldemariam S, Xie F, Roldan A, Roger J, Tang AS, Oskotsky TT, Stevenson DK, Lathi R, Rajkovic A, Aghaeepour N, Eisenberg M, Sirota M. Leveraging Electronic Medical Records from Two Hospital Systems Identifies Male Infertility Associated Comorbidities Across Time. Research Square. 2023. 10.21203/rs.3.rs-3706493/v1
Kodama L, Woldemariam S, Tang A, Li Y, Oskotsky T, Raphael E, Sirota M. Sex-stratified phenotyping of comorbidities associated with an inpatient delirium diagnosis using real world data. medRxiv. 2023. DOI Name: 10.1101/2023.11.02.23297925
Kouznetsov RC, Belonwu S, Li Y, Andreolett G, Oskotsky TT, Kodama L, Sirota M. Identifying Age-Specific Transcriptomic and Metabolomic Changes Induced by apoE Genotype in Mice. SSRN. 2023. DOI Name: 10.2139/ssrn.4465497
Roger J, Xie F, Costello J, Tang A, Liu J, Oskotsky T, Woldemariam S, Kosti I, Le B, Snyder M, Giudice L, Torgerson D, Shaw G, Stevenson D, Rajkovic A, Aghaeepour N, Glymour M, Cakmak H, Lathi R, Sirota M. Leveraging electronic health records to identify risk factors for recurrent pregnancy loss across two medical centers: a case-control study. Research Square. 2023. DOI Name: 10.21203/rs.3.rs-2631220/v1
Cuyler L, Yu K, Okimoto RA, Sirota M. Transcriptional fidelity enhances cancer cell line selection in pediatric cancers. bioRxiv. 2021. DOI Name: 10.1101/2021.10.01.462682v1
Sun M, Shankar R, Ko M, Chang CD, Yeh S, Li S, Liu K, Zhou G, Xing J, VanVelsen A, VanVelsen T, Paithankar S, Feng BY, Young K, Strug M, Turco L, Wang Z, Schadt E, Chen R, Li X, Oskotsky T, Sirota M, Glicksberg BS, Nadkarni GN, Moeser AJ, Li L, Kim S, Zhou J, Chen B. Sex differences in viral entry protein expression, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment in COVID-19. Research Square. 2020. DOI name: 10.21203/rs.3.rs-100914/v2
Daugherty AC, Farrington C, Hakim I, Mujahid S, Noblin ES, Radin AM, Chua MS, Rabe M, Fernald G, Ford D, Sirota M, Schaevitz L, Radin AA. Rapid Identification and Validation of Novel Rheumatoid Arthritis Drug Treatments using an Integrative Bioinformatics Platform. bioRxiv. 2018. DOI name: 10.1101/243998
Publications
2025
Israni S, Bader GD, Baranzini SE, Capra JA, Sirota M, Theodoris CV, Ye CJ. Precision medicine: crossing the biomedical scales with AI. The Journal of Precision Medicine: Health and Disease. 2025; Volume 0, Issue 0, 100010.Narendra R, Van Phan H, Patterson SL, Almonte-Loya A, Lydon EC, Lanata C, Love C, Park J, Shimoda M, Barcellos L, Mekonen H, Detweiler A, Deosthale P, Neff N, Criswell LA, Maliskova L, Eckalbar W, Fragiadakis GK, Yazdany J, Dall'Era M, Katz P, Ye CJ, Sirota M, Langelier CR. Epigenetic attenuation of interferon signaling is associated with aging-related improvements in systemic lupus erythematosus. Sci Transl Med. 2025; 17(804) PMID: 40561001
Yu J, Kather JN, Yuan TF, Sirota M. Celebrating 5 years of Cell Reports Medicine with authors: Past and future. Cell Rep Med. 2025 PMID: 40239626
Thong LY, McRae AF, Sirota M, Giudice L, Montgomery GW, Mortlock S. Methylation Risk Score Modelling in Endometriosis: Evidence for Non-Genetic DNA Methylation Effects in a Case–Control Study. International Journal of Molecular Sciences; 26(8):3760. 2025 PMID: 40180206
Zhou M, Tang AS, Zhang H, Xu Z, Ke AMC, Su C, Huang Y, Mantyh WG, Jaffee MS, Rankin KP, DeKosky ST, Zhou J, Guo Y, Bian J, Sirota M, Wang F. Identifying progression subphenotypes of Alzheimer's disease from large-scale electronic health records with machine learning. J Biomed Inform. 2025 PMID: 40180206
Sur S, Kerwin M, Pineda S, Sansanwal P, Sigdel TK, Sirota M, Sarwal MM. Novel mechanism for tubular injury in nephropathic cystinosis. Elife. 2025. PMID: 40111391
Phongpreecha T, Ghanem M, Reiss JD, Oskotsky T, Mataraso SJ, De Francesco D, Reincke SM, Espinosa C, Chung P, Ng T, Costello JM, Sequoia JA, Razdan S, Xie F, Berson E, Kim Y, Seong D, Szeto MY, Myers F, Gu H, Feister J, Verscaj CP, Rose LA, Sin LWY, Oskotsky B, R oger J, Shu CH, Shome S, Yang LK, Tan Y, Levitte S, Wong RJ, Gaudillière B, Angst MS, Montine TJ, Kerner JA, Keller RL, Shaw GM, Sylvester KG, Fuerch J, Chock V, Gaskari S, Stevenson DK, Sirota M, Prince LS, Aghaeepour N. AI-guided precision parenteral nutrition for neonatal intensive care units. Nat Med.2025. PMID: 40133525
Diop M, Davidson BR, Fragiadakis GK, Sirota M, Gaudillie`re B, Combes AJ. Single-cell omics technologies – Fundamentals on how to create single-cell looking glasses for reproductive health. American Journal of Obstetrics & Gynecology. 2025. PMID: 39526929
Ramey GD, Tang A, Phongpreecha T, Yang MM, Woldemariam SR, Oskotsky TT, Montine TJ, Allen I, Miller ZA, Aghaeepour N, Capra JA, Sirota M. Exposure to autoimmune disorders is associated with increased Alzheimer’s disease risk in a multi-site electronic health record analysis. Cell Reports Medicine. 2025. PMID: 39999839
Costello JM, Takasuka H, Roger J, Yin O, Tang A, Oskotsky T, Sirota M, Capra JA. Pre-conception clinical risk factors differ between spontaneous and indicated preterm birth in a densely phenotyped EHR cohort. BMC Pregnancy Childbirth 25,149. 2025 PMID: 39939846
Nezhat CR, Oskotsky TT, Robinson JF, Fisher SJ, Tsuei A, Lui B, Irwin JC, Gaudilliere B, Sirota M, Stevenson DK, Giudice LC. Real world perspectives on endometriosis disease phenotyping through surgery, omics, health data, and artificial intelligence. npj Womens Health 3, 8. 2025. PMID: 39926583
Miramontes S, Khan U, Ferguson EL, Sirota M, Glymour MM. The association of cholesterol levels with memory and memory change over a 14-year period in a US national cohort. Alzheimer's Dement. 2025. PMID: 39759951
2024
Patterson SL, Van Phan H, Ye CJ, Lanata C, González SC, Park J, Criswell LA, Barbour KE, Yazdany J, Dall'Era M, Sirota M, Katz P, Langelier CR. Physical inactivity exacerbates pathologic inflammatory signalling at the single cell level in patients with systemic lupus. EBioMedicine. 2024 PMID: 39531917Ji X, Lakuleswaran M, Cowell W, Kahn LG, Sirota M, Abrahamsson D. Insights into the Chemical Exposome during Pregnancy: A Non-Targeted Analysis of Preterm and Term Births. Environ Sci Technol. 2024. PMID: 39526929
Huang D, Flynn E, Almonte-Loya A, Davidson B, Chan M, Casillas A, Irwin JC, Fragiadakis GK, Cakmak H, Combes AJ, Cedars MI, Sirota M, Giudice LC. A positive ReceptivaDx result for BCL6 does not correlate with abnormal ERA results or decreased expression of receptivity-associated markers: two sides of the endometrial receptivity coin in fertility evaluation and treatment. F S Sci. 2024. PMID: 39345789
Parraga-Leo A, Oskotsky TT, Oskotsky B, Wibrand C, Roldan A, Tang AS, Ha CWY, Wong RJ, Minot SS, Andreoletti G, Kosti I, Theis KR, Ng S, Lee YS, Diaz-Gimeno P, Bennett PR, MacIntyre DA, Lynch SV, Romero R, Tarca AL, Stevenson DK, Aghaeepour N, Golob JL, Sirota M.VMAP: Vaginal Microbiome Atlas during Pregnancy. JAMIA Open. 2024. PMID: 39345789
Cutts Z, Patterson S, Maliskova L, Taylor KE, Ye CJ, Dall’Era M, Yazdany J, Criswell LA, Fragiadakis GK, Langelier C, Capra JA, Sirota M, Lanata CM. Cell-Specific Transposable Element and Gene Expression Analysis Across Systemic Lupus Erythematosus Phenotypes. ACR Open Rheumatology. 2024. PMID: 39143499
Tang AS, Woldemariam SR, Miramontes S, Norgeot B, Oskotsky TT, Sirota M. Harnessing EHR data for health research. Nat Med. 2024. PMID: 38965433
Binvignat M, Miao B, Wibrand C, Yang M, Rychkov D, Flynn E, Nititham J, Tamaki W, Khan U, Carvidi A, Krueger M, Niemi E, Sun Y, Fragiadakis GK, Sellam J, Mariotti-Ferrandiz E, Klatzmann D, Gross A, Ye CJ, Butte AJ, Criswell L, Nakamura M, Sirota M.. Deciphering Cell-types and Gene Signatures Associated with Disease Activity in Rheumatoid Arthritis using Single Cell RNA-sequencing. JCI Insight. 2023. PMID: 38954480
Miramontes S, Pereda Serras C, Woldemariam SR, Khan U, Li Y, Tang AS, Tsoy E, Oskotsky TT, Sirota M. Alzheimer's disease as a women's health challenge: a call for action on integrative precision medicine approaches. npj Womens Health. 2024. PMID: 38778871
Rabadam G, Wibrand C, Flynn E, Hartoularos GC, Sun Y, Madubata C, Fragiadakis GK, Ye J, Kim S, Gartner ZJ, Sirota M, Neely J. Coordinated immune dysregulation in Juvenile Dermatomyositis revealed by single-cell genomics. JCI Insight. 2024. PMID: 38743491.
Oskotsky TT, Yin O, Khan U, Arnaout L, Sirota M. Data-driven insights can transform women's reproductive health. npj Womens Health. 2024. PMID: 38770215.
Oskotsky TT*, Bhoja A*, Bunis D*, Le BL, Kosti I, Li C, Houshdaran S, Sen S, Vallvé-Juanico J, Wang W, Arthurs E, Mahoney L, Lang L, Gaudilliere B, Stevenson DK, Irwin JC, Giudice LC, McAllister S, Sirota M. Identifying therapeutic candidates for endometriosis through a transcriptomics-based drug repositioning approach. iScience. 2024. PMID: 38510116.
Tang AS, Sirota M. Disease insights from medical data using interpretable risk prediction models. Nature Aging. 2024. PMID: 38383859
Tang AS, Rankin KP, Cerono G, Miramontes S, Mills H, Roger J, Zeng B, Nelson C, Soman K, Woldemariam S, Li Y, Lee A, Bove R, Glymour M, Aghaeepour N, Oskotsky T, Miller Z, Allen I, Sanders SJ, Baranzini S, Sirota M. Leveraging Electronic Medical Records and Knowledge Networks to Predict Disease Onset and Gain Biological Insight Into Alzheimer's Disease. Nature Aging. 2024. PMID: 38383858
Amit G, Yanover C, Bivas-Benita M, Girshovitz I, Helbitz T, Sudry T, Bar V, Tang A, Le B, Roger J, Woldemariam S, Kosti I, Oskotsky TT, Akiva P, Sirota M. Antidepressant use during pregnancy and the risk of preterm birth – a cohort study. npj Womens Health. 2024. DOI Name: 10.21203/rs.3.rs-3058509/v1
Aminbeidokhti M, Qu JH, Belur S, Cakmak H, Jaswa E, Lathi RB, Sirota M, Snyder M, Yatsenko SA, Rajkovic A. Miscarriage risk assessment: a bioinformatic approach to identifying candidate lethal genes and variants. Hum Genet. 2024. PMID: 38302665 Yang MM, Lee S, Neely J, Hinchcliff M, Wolters PJ, Sirota M.. Gene Expression Meta-Analysis Reveals Aging and Cellular Senescence Signatures in Scleroderma-associated Interstitial Lung Disease. Frontiers in Immunology. 2024. PMID: 38348044
Hédou J, Marić I, Bellan G, Einhaus J, Gaudillière DK, Ladant FX, Verdonk F, Stelzer IA, Feyaerts D, Tsai AS, Ganio EA, Sabayev M, Gillard J, Amar J, Cambriel A, Oskotsky TT, Roldan A, Golob JL, Sirota M, Bonham TA, Sato M, Diop M, Durand X, Angst MS, Stevenson DK, Aghaeepour N, Montanari A, Gaudillière B. Discovery of sparse, reliable omic biomarkers with Stabl. Nat Biotechnol. 2024. PMID: 38168992
2023
Bland GD, Abrahamsson D, Wang M, Zlatnik M, Morello-Frosch R, Park JS, Sirota M, Woodruff TJ. Exploring applications of non-targeted analysis in the characterization of the prenatal exposome. Science of The Total Environment. 2023. PMID: 38142008Golob JL*, Oskotsky TT*, Tang AS, Roldan A, Chung V, Ha CWY, Wong RJ, Flynn KJ, Parraga-Leo A, Wibrand C, Minot SS, Oskotsky B, Andreoletti G, Kosti I, Bletz J, Nelson A, Gao J, Wei Z, Chen G, Tang ZZ, Novielli P, Romano D, Pantaleo E, Amoroso N, Monaco A, Vacca M, Angelis MD, Bellotti R, Tangaro S, Kuntzleman A, Bigcraft I, Techtmann S, Bae D, Kim E, Jeon J, Joe S, Theis KR, Ng S, Lee Li YS, Diaz-Gimeno P, Bennett PR, MacIntyre DA, Stolovitzky G, Lynch SV, Albrecht J, Gomez-Lopez N, Romero R, Stevenson DK, Aghaeepour N, Tarca AL, Costello JC, Sirota M. Microbiome Preterm Birth DREAM Challenge: Crowdsourcing Machine Learning Approaches to Advance Preterm Birth Research. Cell Reports Medicine. 2023. PMID: 38134931
Minot SS, Garb B, Roldan A, Tang A, Oskotsky TT, Rosenthal C, Hoffman NG, Sirota M, Golob JL. MaLiAmPi enables generalizable and taxonomy-independent microbiome features from technically diverse 16S-based microbiome studies. Cell Reports Methods. 2023. PMID: 37939711
Schott CR, Koehne AL, Sayles LC, Young EP, Luck C, Yu K, Lee AG, Breese MR, Leung SG, Xu H, Shah AT, Liu HY, Spillinger A, Behroozfard IH, Marini KD, Dinh PT, Pons Ventura MV, Vanderboon EN, Hazard FK, Cho SJ, Avedian RS, Mohler DG, Zimel M, Wustrack R, Curtis C, Sirota M, Sweet-Cordero EA. Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach. Clinical Cancer Research. 2023. PMID: 37703185
Giudice LC, Oskotsky TT, Falako S, Opoku-Anane J, Sirota M. Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations. FASEB J. 2023. PMID: 37641572.
Mortlock S, Houshdaran S, Kosti I, Rahmioglu N, Nezhat C, Vitonis AF, Andrews SV, Grosjean P, Paranjpe M, Horne AW, Jacoby A, Lager J, Opoku-Anane J, Vo KC, Manvelyan E, Sen S, Ghukasyan Z, Collins F, Santamaria X, Saunders P, Kober K, McRae AF, Terry KL, Vallvé-Juanico J, Becker C, Rogers PAW, Irwin JC, Zondervan K, Montgomery GW, Missmer S, Sirota M, Giudice L. Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function. Commun Biol. 2023. PMID: 37587191.
Trowbridge J, Abrahamsson D, Bland GD, Jiang T, Wang M, Park JS, Morello-Frosch R, Sirota M, Lee H, Goin DE, Zlatnik MG, Woodruff TJ. Extending Nontargeted Discovery of Environmental Chemical Exposures during Pregnancy and Their Association with Pregnancy Complications-A Cross-Sectional Study. Environ Health Perspect. 2023. PMID: 37466315.
Yu K, Basu A, Yau C, Wolf DM, Goodarzi H, Bandyopadhyay S, Korkola JE, Hirst GL, Asare S, Demichele A, Hylton N, Yee D, Esserman L, Van't Veer L, Sirota M. Computational drug repositioning for the identification of new agents to sensitize drug-resistant breast tumors across treatments and receptor subtypes. Front. Oncol. Sec. Cancer Molecular Targets and Therapeutics. 2023. PMID: 37384294
Baglaenko Y, Wagner C, Bhoj VG, Brodin P, Gershwin ME, Graham D, Invernizzi P, Kidd KK, Korunsky I, Levy M, Mammen AL, Nizet V, Ramirez-Valle F, Stites EC, Williams MS, Wilson M, Rose NR, Ladd V, Sirota M. Making inroads to precision medicine for the treatment of autoimmune diseases: harnessing genomic studies to better diagnose and treat complex disorders. Cambridge Prisms: Precision Medicine. 2023. DOI name: 10.1017/pcm.2023.14
Vora B, Wen A, Yee SW, Trinh K, Azimi M, Green EAE, Sirota M, Greenberg AS, Newman JW, Giacomini KM. The Effect of Trimethoprim on Thiamine Absorption: A Transporter-Mediated Drug-Nutrient Interaction. Clin Pharmacol Ther. 2023. PMID: 37151050
Sperry MM*, Oskotsky TT*, Marić I, Kaushal S, Takeda T, Horvath V, Powers RK, Rodas M, Furlong B, Soong M, Prabhala P, Goyal G, Carlson KE, Wong RJ, Kosti I, Le BL, Logue J, Hammond H, Frieman M, Stevenson DK, Ingber DE, Sirota M**, Novak R**. Target-agnostic drug prediction integrated with medical record analysis uncovers differential associations of statins with increased survival in COVID-19 patients. PLoS Comput Biol. 2023. PMID: 37146076 Laurent SA, Strauli NB, Eggers EL, Wu H, Michel B, Demuth S, Palanichamy A, Wilson MR, Sirota M, Hernandez RD, Cree BAC, Herman AE, von Büdingen HC. Effect of Ocrelizumab on B- and T-Cell Receptor Repertoire Diversity in Patients With Relapsing Multiple Sclerosis From the Randomized Phase III OPERA Trial. Neurol Neuroimmunol Neuroinflamm. 2023 PMID: 37094998
Woldemariam SR, Tang AS, Oskotsky TT, Yaffe K, Sirota M. Similarities and differences in Alzheimer's dementia comorbidities in racialized populations identified from electronic medical records. Commun Med. 2023 PMID: 37031271
Rahmioglu N, Mortlock S, Ghiasi M, Møller PL, Stefansdottir L, Galarneau G, Turman C, Danning R, Law MH, Sapkota Y, Christofidou P, Skarp S, Giri A, Banasik K, Krassowski M, Lepamets M, Marciniak B, Nõukas M, Perro D, Sliz E, Sobalska-Kwapis M, Thorleifsson G, Topbas-Selcuki NF, Vitonis A, Westergaard D, Arnadottir R, Burgdorf KS, Campbell A, Cheuk CSK, Clementi C, Cook J, De Vivo I, DiVasta A, Dorien O, Donoghue JF, Edwards T, Fontanillas P, Fung JN, Geirsson RT, Girling JE, Harkki P, Harris HR, Healey M, Heikinheimo O, Holdsworth-Carson S, Hostettler IC, Houlden H, Houshdaran S, Irwin JC, Jarvelin MR, Kamatani Y, Kennedy SH, Kepka E, Kettunen J, Kubo M, Kulig B, Kurra V, Laivuori H, Laufer MR, Lindgren CM, MacGregor S, Mangino M, Martin NG, Matalliotaki C, Matalliotakis M, Murray AD, Ndungu A, Nezhat C, Olsen CM, Opoku-Anane J, Padmanabhan S, Paranjpe M, Peters M, Polak G, Porteous DJ, Rabban J, Rexrode KM, Romanowicz H, Saare M, Saavalainen L, Schork AJ, Sen S, Shafrir AL, Siewierska-Górska A, Słomka M, Smith BH, Smolarz B, Szaflik T, Szyłło K, Takahashi A, Terry KL, Tomassetti C, Treloar SA, Vanhie A, Vincent K, Vo KC, Werring DJ, Zeggini E, Zervou MI; DBDS Genomic Consortium; FinnGen Study; FinnGen Endometriosis Taskforce; Celmatix Research Team; 23andMe Research Team; Adachi S, Buring JE, Ridker PM, D'Hooghe T, Goulielmos GN, Hapangama DK, Hayward C, Horne AW, Low SK, Martikainen H, Chasman DI, Rogers PAW, Saunders PT, Sirota M, Spector T, Strapagiel D, Tung JY, Whiteman DC, Giudice LC, Velez-Edwards DR, Uimari O, Kraft P, Salumets A, Nyholt DR, Mägi R, Stefansson K, Becker CM, Yurttas-Beim P, Steinthorsdottir V, Nyegaard M, Missmer SA, Montgomery GW, Morris AP, Zondervan KT. The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions. Nat Genet. 2023. PMID: 36914876
De Francesco D, Reiss JD, Roger J, Tang AS, Chang AL, Becker M, Phongpreecha T, Espinosa C, Morin S, Berson E, Thuraiappah M, Le BL, Ravindra NG, Payrovnaziri SN, Mataraso S, Kim Y, Xue L, Rosenstein MG, Oskotsky T, Marić I, Gaudilliere B, Carvalho B, Bateman BT, Angst MS, Prince LS, Blumenfeld YJ, Benitz WE, Fuerch JH, Shaw GM, Sylvester KG, Stevenson DK, Sirota M, Aghaeepour N. Data-driven longitudinal characterization of neonatal health and morbidity. Sci Transl Med. 2023. PMID: 36791208
Benítez R, Yu K, Sirota M, Malats N, Pineda S. Characterization of the tumor-infiltrating immune repertoire in muscle invasive bladder cancer. Front Immunol. 2023. DOI name: 10.3389/fimmu.2023.986598
Maïer B, Tsai AS, Einhaus JF, Desilles JP, Ho-Tin-Noé B, Gory B, Sirota M, Leigh R, Lemmens R, Albers G, Olivot JM, Mazighi M, Gaudillière B. Neuroimaging is the new "spatial omic": multi-omic approaches to neuro-inflammation and immuno-thrombosis in acute ischemic stroke. Semin Immunopathol. 2023. PMID: 36786929
2022
Tang A, Woldemariam S, Roger J, Sirota M. Translational Bioinformatics to Enable Precision Medicine for All: Elevating Equity across Molecular, Clinical, and Digital Realms. Yearb Med Inform. 2022. PMID: 36463867 Sigdel TK, Fields PA, Liberto J, Damm I, Kerwin M, Hood J, Towfighi P, Sirota M, Robins HS, Sarwal MM. Perturbations of the T-cell immune repertoire in kidney transplant rejection. Front Immunol. 2022 PMID: 36466928 Abraham A, Le B, Kosti I, Straub P, Velez-Edwards DR, Davis LK, Newton JM, Muglia LJ, Rokas A, Bejan CA, Sirota M, Capra JA. Dense phenotyping from electronic health records enables machine learning-based prediction of preterm birth. BMC Med. 2022. PMID: 36167547Goin DE, Abrahamsson D, Wang M, Jiang T, Park JS, Sirota M, Morello-Frosch R, DeMicco E, Zlatnik MG, Woodruff TJ. Disparities in chemical exposures among pregnant women and neonates by socioeconomic and demographic characteristics: A nontargeted approach. Environ Res. 2022. PMID: 36049512
Patterson SL, Sun S, Rychkov D, Katz P, Tsitsiklis A, Nakamura MC, Serpa PH, Langelier CR, Sirota M. Physical Activity Associates with Lower Systemic Inflammatory Gene Expression in Rheumatoid Arthritis. J Rheumatol. 2022 PMID: 35777820
Neely J, Hartoularos G, Bunis D, Sun Y, Lee D, Kim S, Ye J, Sirota M. Multi-Modal Single-Cell Sequencing Identifies Cellular Immunophenotypes Associated With Juvenile Dermatomyositis Disease Activity. Front. Immunol. 2022. PMID: 35799782
Andrews S, Yang IJ, Froehlich K, Oskotsky T, and Sirota M. Large-scale placenta DNA methylation mega-analysis reveals fetal sex-specific differentially methylated CpG sites and regions. Scientific Reports. 2022. PMID: 35672357
Abrahamsson D, Siddharth A, Young TM, Sirota M, Park JS, Martin JW, Woodruff TJ. In Silico Structure Predictions for Non-targeted Analysis: From Physicochemical Properties to Molecular Structures. J Am Soc Mass Spectrom. 2022. PMID: 35649165
Lanata CM, Nititham J, Taylor KE, Solomon O, Chung SA, Blazer A, Trupin L, Katz P, Dall'Era M, Yazdany J, Sirota M, Barcellos LF, Criswell LA. The dynamics of methylation of CpG sites associated with SLE subtypes in a longitudinal cohort. Arthritis Rheumatol. 2022. PMID: 35635730
Belonwu SA, Li Y, Bunis DG, Rao AA, Solsberg CW, Oskotsky T, Taubes AL, Grone B, Zalocusky KA, Fragiadakis GK, Huang Y, Sirota M. Bioinformatics Analysis of Publicly Available Single-Nuclei Transcriptomics Alzheimer's Disease Datasets Reveals APOE Genotype-Specific Changes Across Cell Types in Two Brain Regions. Frontiers in Aging Neuroscience. 2022. PMID: 35572130
Goin DE, Abrahamsson D, Wang M, Park JS, Sirota M, Morello-Frosch R, DeMicco E, Trowbridge J, August L, O’Connell S, Ladella S, Zlatnik MG, Woodruff TJ. Investigating geographic differences in environmental chemical exposures in maternal and cord sera using non-targeted screening and silicone wristbands in California. Journal of Exposure Science & Environmental Epidemiology. 2022. PMID: 35449448
Zinter MS, Versluys AB, Lindemans CA, Mayday MY, Reyes G, Sunshine S, Chan M, Fiorino EK, Cancio M, Prevaes S, Sirota M, Matthay MA, Kharbanda S, Dvorak CC, Boelens JJ, DeRisi JL. Pulmonary microbiome and gene expression signatures differentiate lung function in pediatric hematopoietic cell transplant candidates. Sci Transl Med. 2022. PMID: 35263147
Ishiyama K, Arakawa-Hoyt J, Aguilar OA, Damm I, Towfighi P, Sigdel T, Tamaki S, Babdor J, Spitzer MH, Reed EF, Sarwal MM, Lanier LL; CMV Systems Immunobiology Group. Mass cytometry reveals single-cell kinetics of cytotoxic lymphocyte evolution in CMV-infected renal transplant patients. Proc Natl Acad Sci USA. 2022. PMID: 35181606
Tang AS, Oskotsky T, Havaldar S, Mantyh W, Bicak M, Warly-Solsberg C, Woldemariam S, Zeng B, Hu Z, Oskotsky B, Dubal D, Allen IE, Glicksberg B, and Sirota M. Deep phenotyping of Alzheimer's Disease Leveraging Electronic Medical Records Data Identifies Sex-Specific Clinical Associations. Nat Commun. 2022. PMID: 35115528
Oskotsky T*, Bajaj R*, Burchard J*, Cavazos T*, Chen I*, Connell W*, Eaneff S*, Grant T*, Kanungo I*, Lindquist K*, Myers-Turnbull D*, Naing ZZC*, Tang A*, Vora B*, Wang J*, Karim I*, Swadling C*, Yang J*, Lindstaedt B and Sirota M. Nurturing diversity and inclusion in AI in Biomedicine through a virtual summer program for high school students. PLOS Computational Biology. 2022. PMID: 35100256
Bunis D, Wang W, Vallve-Juanico J, Houshdaran S, Sen S, Soltane IB, Kosti I, Vo KC, Irwin J, Giudice LC, and Sirota M. Whole-tissue deconvolution and scRNAseq analysis identify altered endometrial cellular compositions and functionality associated with endometriosis. Front. Immunol. 2022. PMID: 35069565
Yu K, Ravoor A, Malats N, Pineda S, and Sirota M. A pan-cancer analysis of tumor-infiltrating B cell repertoires. Front. Immunol. 2022. PMID: 35069569
2021
Ahn R, Schaenman J, Qian Z, Pickering H, Groysberg V, Rossetti M, Llamas M, Hoffmann A, Gjertson D, Deng M, Bunnapradist S, Reed EF; CMV Systems Immunobiology Group. Acute and Chronic Changes in Gene Expression After CMV DNAemia in Kidney Transplant Recipients. Front Immunol. 2021 PMID: 34867983Oskotsky TT*, Marić I*, Tang A, Oskotsky B, Wong RJ, Aghaeepour N, Sirota M**, Stevenson DK**. Mortality Risk Among Patients With COVID-19 Prescribed Selective Serotonin Reuptake Inhibitor Antidepressants. JAMA Network Open. 2021. PMID: 34779847
Belonwu S, Li Y, Bunis D, Rao AA, Warly-Solsberg C, Tang A, Fragiadakis G, Dubal D, Oskotsky T, and Sirota M. Sex-stratified single-cell RNA-Seq analysis identifies sex-specific and cell type-specific transcriptional responses in Alzheimer's disease across two brain regions. Mol Neurobiol. 2021. PMID: 34669146
Le BL, Sper R, Nielsen SCA, Pineda S, Nguyen, QH, Lee JY, Boyd SD, Mackenzie, TC and Sirota M. Maternal and Infant Immune Repertoire Sequencing Analysis Identifies Distinct Ig and TCR Development in Term and Preterm Infants. J Immunol. 2021. PMID: 34654689
Taubes A Nova P, Zalocusky K. A, Kosti I, Bicak M, Zilberter M. Y, Hao Y, Yoon SY, Oskotsky T, Pineda S, Chen B, Jones AEA, Choudhary K, Grone B, Balestra ME, Chaudhry F, Paranjpe I, De Freitas J, Koutsodendris N, Chen N, Wang C, Chang W, An A, Glicksberg BS, Sirota M, Huang Y. Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer's disease. Nature Aging. 2021. PMID: 36172600
Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S. A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. Elife. 2021. PMID: 34550070
Pineda S, López De Maturana E, Yu K, Ravoor A, Wood I, Malats N and Sirota M. Tumor-infiltrating B and T cell repertoire in pancreatic cancer associated with host and tumor features. Front Immunol. 2021. PMID: 34630409
Paranjpe MD, Belonwu S, Wang JK, Oskotsky T, Gupta A, Taubes A, Zalocusky K, Paranjpe I, Glicksberg BS, Huang Y, Sirota M. Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women with Alzheimer's Disease. Front Aging Neurosci. 2021. PMID: 34658838
Tang A, Oskotsky T, Sirota M. Personalizing routine lab tests with machine learning. Nat Med. 2021. PMID: 34518677
Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA; COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nat Commun. 2021. PMID: 34446707
Davis EJ, Solsberg CW, White CC, Miñones-Moyano E, Sirota M, Chibnik L, Bennett DA, De Jager PL, Yokoyama JS, Dubal, DB. Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease. JAMA Neurol. 2021. PMID: 34424272
Gillis-Buck E, Miller H, Sirota M, Sanders SJ, Ntranos V, Anderson MS, Gardner JM, MacKenzie TC. Extrathymic Aire-expressing cells support maternal-fetal tolerance. Sci Immunol. 2021. PMID: 34272228
Abrahamsson D, Wang A, Jiang T, Wang M, Siddharth A, Morello-Frosch R, Park JS, Sirota M, Woodruff TJ. Comprehensive Non-Targeted Analysis Study of the Prenatal Exposome. Environ Sci Technol. 2021. PMID: 34260856
Tarca AL, Pataki BA, Romero R, Sirota M, Guan Y, Kutum R, Gomez-Lopez N, Done B, Bhatti G, Yu T, Andreoletti G, Chaiworapongsa T, The DREAM Preterm Birth Prediction Challenge Consortium, Hassan SS, Hsu CD, Aghaeepour N, Stolovitzky G, Csabai I, Costello JC. Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth. Cell Reports Medicine. 2021. PMID: 34195686
Le BL*, Andreoletti G*, Oskotsky T*, Vallejo-Gracia A, Rosales R, Yu KZ, Kosti I, Leon KE, Bunis DG, Li C, Kumar GR, White KM, García-Sastre AE, Ott M, Sirota M. Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19. Scientific Reports. 2021. PMID: 34112877
Rychkov D, Neely J, Oskotsky T, Yu S, Perlmutter N, Nititham J, Carvidi A, Krueger M, Gross A, Criswell LA, Ashouri JF, Sirota M. Cross-Tissue Transcriptomic Analysis Leveraging Machine Learning Approaches Identifies New Biomarkers for Rheumatoid Arthritis. Frontiers in Immunology. 2021. PMID: 34177888
Vora B, Brackman DJ, Zou L, Garcia‐Cremades M, Sirota M, Savic RM, Giacomini KM. Oxypurinol pharmacokinetics and pharmacodynamics in healthy volunteers: Influence of BCRP Q141K polymorphism and patient characteristics. Clinical and Translational Science. 2021. PMID: 33931953
Andreoletti G, Lanata CM, Trupin L, Paranjpe I, Jain TS, Nititham J, Taylor KE, Combes AJ, Maliskova L, Ye CJ, Katz P, Era MD, Yazdany J, Criswell LA, Sirota M. Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus erythematosus patients identifies ethnicity- and disease-specific expression signatures. Communications Biology. 2021. PMID: 33883687
Yee SW, Vora B, Oskotsky T, Zou L, Jakobsen S, Enogieru OJ, Koleske ML, Kosti I, Rödin M, Sirota M, Giacomini KM. Drugs in COVID19 clinical trials: Predicting transporter‐mediated drug‐drug interactions using in vitro assays and real‐world data. Clinical Pharmacology and Therapeutics. 2021. PMID: 33759449
Wang A, Abrahamsson D, Jiang T, Wang M, Morello-Frosch R, Park JS, Sirota M, Woodruff TJ. Suspect Screening, Prioritization, and Confirmation of Environmental Chemicals in Maternal-Newborn Pairs from San Francisco. Environ Sci Technol. 2021. PMID: 33726493
Enogieru OJ, Koleske ML, Vora B, Ngo H, Yee SW, Chatad D,Sirota M, Giacomini KM. The Effects of Genetic Mutations and Drugs on the Activity of the Thiamine Transporter, SLC19A2. AAPS. 2021. DOI: 10.1208/s12248-021-00562-4 Marić I*, Oskotsky T*, Kosti I, Le B, Wong RJ, Shaw GM, Sirota M**, Stevenson DK**. Decreased Mortality Rate Among COVID-19 Patients Prescribed Statins: Data From Electronic Health Records In The US. Frontiers in Medicine. 2021. PMID: 33614688 Rychkov D, Sur S, Sirota M, Sarwal MM. Molecular Diversity of Clinically Stable Human Kidney Allografts. JAMA Network Open. 2021. PMID: 33492376
Bunis D, Bronevetsky Y, Krow-Lucal E, Bhakta NR, Kim CC, Nerella S, Jones N, Mendoza VF, Bryson YJ, Gern JE, Rutishauser RL, Ye CJ, Sirota M, McCune JM, Burt TD. Single-Cell Mapping of Progressive Fetal-to-Adult Transition in Human Hematopoiesis. Cell Reports. 2021. PMID: 33406429
Zinter MS, Lindemans C, Versluys B, Mayday MY, Sunshine S, Reyes G, Sirota M, Sapru A, Matthay MA, Kharbanda S, Dvorak CC, Jan Boelens JJ, DeRisi JL. The Pulmonary Metatranscriptome Prior to Pediatric Hematopoietic Cell Transplantation Identifies Post-HCT Lung Injury. Blood. 2021. DOI name: 10.1182/blood.2020009246
2020
Bunis DG, Andrews J, Fragiadakis GK, Burt TD, Sirota M. dittoSeq: Universal User-Friendly Single-Cell and Bulk RNA Sequencing Visualization Toolkit. Bioinformatics. 2020. DOI name: 10.1093/bioinformatics/btaa1011 Pineda S, Sur S, Sigdel T, Nguyen M, Crespo E, Torija A, Meneghini M, Gomà M, Sirota M, Bestard O, Sarwal MM. Peripheral Blood RNA Sequencing Unravels a Differential Signature of Coding and Noncoding Genes by Types of Kidney Allograft Rejection. Kidney International Reports. 2020. DOI name: 10.1016/j.ekir.2020.07.023 Kober KM, Lee M-C, Olshen A, Conley YP, Sirota M, Keiser M, Hammer MJ, Abrams G, Schumacher M, Levine JD, Miaskowski C. Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pain. Molecular Pain. 2020. PMID: 32586194 Pineda S, Bunis D, Kosti I, Sirota M. Data Integration for Immunology. Annual Review of Biomedical Data Science. 2020. DOI name: 10.1146/annurev-biodatasci-012420-122454 Abrahamsson D, Park JS, Singh R, Sirota M, Woodruff T. Applications of Machine Learning to in silico Quantification of Chemicals without Analytical Standards. Journal of Chemical Information and Modeling. 2020. PMID: 32379974 Stevenson DK, Wong RJ, Aghaeepour N, Maric I, Angst MS, Contrepois K, Darmstadt GL, Druzin ML, Eisenberg ML, Gaudilliere B, Gibbs RS, Gotlib IH, Gould JB, Lee HC, Ling XB, Mayo JA, Moufarrej MN, Quaintance CC, Quake SR, Relman DA, Sirota M, Snyder MP, Sylvester KG, Hao S, Wise PH, Shaw GM, Katz M. Towards personalized medicine in maternal and child health: integrating biologic and social determinants. Pediatr Res. 2020. PMID: 32454518 Norgeot B, Muenzen K, Peterson TA, Fan X, Glicksberg B, Schenk G, Rutenberg E, Oskotsky B, Sirota M, Yazdany J, Schmajuk G, Ludwig D, Goldstein T, Butte AJ. Protected Health Information filter (Philter): accurately and securely de-identifying free-text clinical notes. Nature Partner Journals Digital Medicine. 2020. DOI name: 10.1038/s41746-020-0258-y Kosti I, Lyalina S, Pollard KS, Butte AJ, Sirota M. Meta-Analysis of Vaginal Microbiome Data Provides New Insights Into Preterm Birth. Frontiers in Microbiology. 2020. PMID: 32322240 Sarin V, Yu K, Ferguson ID, Gugliemini O, Nix MA, Hann B, Sirota M, Wiita AP . Evaluating the efficacy of multiple myeloma cell lines as models for patient tumors via transcriptomic correlation analysis. Leukemia. 2020. PMID: 32123307 Le BL, Iwatani S, Wong RJ, Stevenson DK, Sirota M. Computational discovery of therapeutic candidates for preventing preterm birth. JCI Insight. 2020. PMID: 32051340 Garg A, Fazio S, Duell PB, Baass A, Udata C, Joh T, Riel T, Sirota M, Dettling D, Liang H, Garzone PD, Gumbiner B, Wan H. Molecular Characterization of Familial Hypercholesterolemia in a North American Cohort. J Endocr Soc. 2019. PMID: 319935492019
Neely J, Rychkov D, Paranjpe M, Waterfield M, Kim S, Sirota M. Gene Expression Meta‐Analysis Reveals Concordance in Gene Activation, Pathway, and Cell‐Type Enrichment in Dermatomyositis Target Tissues ACR Open Rheumatology. PMID 31872188. Vora B, Green EAE, Khuri N, Ballgren F, Sirota M, Giacomini KM. Drug-nutrient interactions: discovering prescription drug inhibitors of the thiamine transporter ThTR-2 (SLC19A3). Am J Clin Nutr. 2019. PMID: 31764942. Paik H, Kan MJ, Rappoport N, Hadley D, Sirota M, Chen B, Manber U, Cho SB, Butte AJ. Tracing diagnosis trajectories over millions of patients reveal an unexpected risk in schizophrenia. Sci Data. 2019. PMID: 31615985. Tsur A, Batsry L, Toussia-Cohen S, Rosenstein MG, Barak O, Brezinov Y, Yoeli-Ullman R, Sivan E, Sirota M, Druzin ML, Stevenson DK, Blumenfeld YJ, Aran D. Development and validation of a machine learning model for prediction of shoulder dystocia. Ultrasound Obstet Gynecol. 2019. PMID: 31587401. Lanata CM, Paranjpe I, Nititham J, Taylor KE, Gianfrancesco M, Paranjpe M, Andrews S, Chung SA, Rhead B, Barcellos LF, Trupin L, Katz P, Dall'Era M, Yazdany J, Sirota M, Criswell LA. A phenotypic and genomics approach in a multi-ethnic cohort to subtype systemic lupus erythematosus. Nat Commun. 2019. PMID: 31467281. Ashouri JF, Hsu LY, Yu S, Rychkov D, Chen Y, Cheng DA, Sirota M, Hansen E, Lattanza L, Zikherman J, Weiss A. Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis. Proc Natl Acad Sci U S A. 2019. PMID: 31455730. Yu K, Chen B, Aran D, Charalel J, Yau C, Wolf DM, van 't Veer LJ, Butte AJ, Goldstein T, Sirota M. Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types. Nat Commun. 2019. PMID: 31395879. Paranjpe MD, Taubes A, Sirota M. Insights into Computational Drug Repurposing for Neurodegenerative Disease. Trends Pharmacol Sci. 2019. PMID: 31326236. Pineda S, Sigdel TK, Liberto JM, Vincenti F, Sirota M, Sarwal MM. Characterizing pre-transplant and post-transplant kidney rejection risk by B cell immune repertoire sequencing. Nat Commun. 2019. PMID: 31015506. Chen J, Bhattacharya S, Sirota M, Laiudompitak S, Schaefer H, Thomson E, Wiser J, Sarwal MM, Butte AJ. Assessment of Postdonation Outcomes in US Living Kidney Donors Using Publicly Available Data Sets. JAMA Netw Open. 2019. PMID: 30977847. Andorf S, Bhattacharya S, Gaudilliere B, Shaw GM, Stevenson DK, Butte AJ, Sirota M. A pilot study showing a stronger H1N1 influenza vaccination response during pregnancy in women who subsequently deliver preterm. J Reprod Immunol. 2019. PMID: 30852461. BGhaemi MS, DiGiulio DB, Contrepois K, Callahan B, Ngo TTM, Lee-McMullen B, Lehallier B, Robaczewska A, Mcilwain D, Rosenberg-Hasson Y, Wong RJ, Quaintance C, Culos A, Stanley N, Tanada A, Tsai A, Gaudilliere D, Ganio E, Han X, Ando K, McNeil L, Tingle M, Wise P, Maric I, Sirota M, Wyss-Coray T, Winn VD, Druzin ML, Gibbs R, Darmstadt GL, Lewis DB, Partovi Nia V, Agard B, Tibshirani R, Nolan G, Snyder MP, Relman DA, Quake SR, Shaw GM, Stevenson DK, Angst MS, Gaudilliere B, Aghaeepour N. Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy. Bioinformatics. 2019. PMID: 30561547.2018
Baer RJ, McLemore MR, Adler N, Oltman SP, Chambers BD, Kuppermann M, Pantell MS, Rogers EE, Ryckman KK, Sirota M, Rand L, Jelliffe-Pawlowski LL. Pre-pregnancy or first-trimester risk scoring to identify women at high risk of preterm birth. Eur J Obstet Gynecol Reprod Biol. 2018. PMID: 30439652. Sirota M, Thomas CG, Liu R, Zuhl M, Banerjee P, Wong RJ, Quaintance CC, Leite R, Chubiz J, Anderson R, Chappell J, Kim M, Grobman W, Zhang G, Rokas A, Muglia L, Ober C, England SK, Parry S, Macones G, Driscol D, Shaw GM, Stevenson DK, Simpson JL, Thomson E, Butte AJ; March of Dimes Prematurity Research Centers. Enabling precision medicine in neonatology, an integrated repository for preterm birth research. Sci Data. 2018. PMID: 30398470. Padula AM, Huang H, Baer RJ, August LM, Jankowska MM, Jellife-Pawlowski LL, Sirota M, Woodruff TJ. Environmental pollution and social factors as contributors to preterm birth in Fresno County. Environ Health. 2018. PMID: 30157858 . Huang H, Woodruff TJ, Baer RJ, Bangia K, August LM, Jellife-Palowski LL, Padula AM, Sirota M. Investigation of association between environmental and socioeconomic factors and preterm birth in California. Environ Int. 2018. PMID: 30044231. Pineda S, Sirota M . Determining Significance in the New Era for p-Values. J Pediatr Gastroenterol Nutr. 2018. PMID: 30052572. Wang A, Gerona RR, Schwartz JM, Lin T, Sirota M , Morello-Frosch R, Woodruff TJ. A Suspect Screening Method for Characterizing Multiple Chemical Exposures among a Demographically Diverse Population of Pregnant Women in San Francisco. Environ Health Perspect. 2018. PMID: 30044231. Vora B, Wang A, Kosti I, Huang H, Paranjpe I, Woodruff TJ, MacKenzie T, Sirota M. Meta-Analysis of Maternal and Fetal Transcriptomic Data Elucidates the Role of Adaptive and Innate Immunity in Preterm Birth. Front Immunol. 2018. PMID: 29867970. Kosti I, Sirota M. Electronic Medical Records Enable Precision Medicine Approaches for Celiac Disease. J Pediatr Gastroenterol Nutr. 2018. PMID: 29746345. Huang H, Wang A, Morello-Frosch R, Lam J, Sirota M, Padula A, Woodruff TJ. Cumulative Risk and Impact Modeling on Environmental Chemical and Social Stressors. Curr Environ Health Rep. 2018. PMID: 29441463.Kido T, Sikora-Wohlfeld W, Kawashima M, Kikuchi S, Kamatani N, Patwardhan A, Chen R, Sirota M, Kodama K, Hadley D, Butte AJ. Are minor alleles more likely to be risk alleles? BMC Med Genomics. PMID: 29351777.
Rappoport N*, Toung J*, Hadley D, Wong RJ, Fujioka K, Reuter J, Abbott CW, Oh S, Hu D, Eng C, Huntsman S, Bodian DL, Niederhuber JE, Hong X, Zhang G, Sikora-Wohfeld W, Gignoux CR, Wang H, Oehlert J, Jelliffe-Pawlowski LL, Gould JB, Darmstadt GL, Wang X, Bustamante CD, Snyder MP, Ziv E, Patsopoulos NA, Muglia LJ, Burchard E, Shaw GM, O'Brodovich HM, Stevenson DK, Butte AJ*, Sirota M*. A genome-wide association study identifies only two ancestry specific variants associated with spontaneous preterm birth. Sci Rep. 2018. PMID:29317701.
2017
Pineda S, Sigdel T, Chen J, Jackson A, Sirota M*, Sarwal M*. Novel Non-Histocompatibility Antigen Mismatched Variants Improve the Ability to Predict Antibody-Mediated Rejection Risk in Kidney Transplant. Frontiers in Immunology, 2017. PMID: 29259604.Crawford N, Prendergast D, Oehlert JW, Shaw GM, Stevenson DK, Rappaport N, Sirota M, Tishkoff SA, Sondheimer N. Divergent Patterns of Mitochondrial and Nuclear Ancestry Are Associated with the Risk for Preterm Birth. J Pediatr. 2017. PMID: 29249523.
Van Blarcom T, Lindquist K, Melton Z, Cheung WL, Wagstrom C, McDonough D, Oseguera CV, Ding S, Rossi A, Potluri S, Sundar P, Pitts S, Sirota M, Casas MG, Yan Y, Jones J, Roe-Zurz Z, Srinivasan SS, Zhai W, Pons J, Rajpal A, Chaparro-Riggers J. Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies. MAbs. 2017. PMID: 29227213.
Mirza AN, Fry MA, Urman NM, Atwood SX, Roffey J, Ott GR, Chen B, Lee A, Brown AS, Aasi SZ, Hollmig T, Ator MA, Dorsey BD, Ruggeri BR, Zificsak CA, Sirota M, Tang JY, Butte A, Epstein E, Sarin KY, Oro AE. Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight. 2017. PMID: 29093271.
Aran D, Camarda R, Odegaard J, Paik H, Oskotsky B, Krings G, Goga A, Sirota M, Butte AJ. Comprehensive analysis of normal adjacent to tumor transcriptomes. Nat Commun. 2017. PMID: 29057876.
Hadley D, Pan J, El-Sayed O, Aljabban J, Aljabban I, Azad TD, Hadied MO, Raza S, Rayikanti BA, Chen B, Paik H, Aran D, Spatz J, Himmelstein D, Panahiazar M, Bhattacharya S, Sirota M, Musen MA, Butte AJ. Precision annotation of digital samples in NCBI's gene expression omnibus. Sci Data. 2017. PMID: 28925997.
Gianfrancesco MA, Schmajuk G, Haserodt S, Trupin L, Izadi Z, Jafri K, Shiboski S, Sirota M, Adams Dudley R, Yazdany J. Hydroxychloroquine dosing in immune-mediated diseases: implications for patient safety. Rheumatol Int. 2017.PMID:28748425.
Apeltsin L, Wang S, von Büdingen HC, Sirota M. A Haystack Heuristic for Autoimmune Disease Biomarker Discovery Using Next-Gen Immune Repertoire Sequencing Data. Sci Rep. 2017. PMID: 28706301.
Chen B, Ma L, Paik H, Sirota M, Wei W, Chua MS, So S, Butte AJ. Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets. Nat Commun. 2017. PMID: 28699633.
Schmajuk G, Tonner C, Trupin L, Li J, Sarkar U, Ludwig D, Shiboski S, Sirota M, Dudley RA, Murray S, Yazdany J. Using health-system-wide data to understand hepatitis B virus prophylaxis and reactivation outcomes in patients receiving rituximab. Medicine (Baltimore), 2017.PMID: 28353614.
Sirota M, Sarwal M. Transplantomics: Towards Precision Medicine in Transplantation Research. Transplantation, 2017. PMID: 28121910.
2016
Low YS, Daugherty AC, Schroeder EA, Chen W, Seto T, Weber S, Lim M, Hastie T, Mathur M, Desai M, Farrington C, Radin AA, Sirota M, Kenkare P, Thompson CA, Yu PP, Gomez SL, Sledge GW Jr, Kurian AW, Shah NH. Synergistic drug combinations from electronic health records and gene expression. J Am Med Inform Assoc, 2016. PMID: 27940607.Yeung YA, Foletti D, Deng X, Abdiche Y, Strop P, Glanville J, Pitts S, Lindquist K, Sundar PD, Sirota M, Hasa-Moreno A, Pham A, Melton Witt J, Ni I, Pons J, Shelton D, Rajpal A, Chaparro-Riggers J. Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire. Nat Commun, 2016. PMID: 27857134.
Paik H, Chen B, Sirota M, Hadley D, Butte AJ. Integrating Clinical Phenotype and Gene Expression Data to Prioritize Novel Drug Uses. CPT Pharmacometrics Syst Pharmacol, 2016. PMID: 27860440.
Wang A, Padula A, Sirota M, Woodruff TJ. Environmental influences on reproductive health: the importance of chemical exposures. Fertil Steril, 2016. Review. PMID: 27513554.
Kosti I, Jain N, Aran D, Butte AJ, Sirota M. Cross-tissue Analysis of Gene and Protein Expression in Normal and Cancer Tissues. Sci Rep, 2016. PMID: 27142790.
Bagley SC*, Sirota M*, Chen R, Butte AJ, Altman RB. Constraints on Biological Mechanism from Disease Comorbidity Using Electronic Medical Records and Database of Genetic Variants. PLoS Comput Biol, 2016. PMID: 27115429.
Cho HG, Fiorentino D, Lewis M, Sirota M*, Sarin KY*. Identification of alpha-adrenergic agonists as potential therapeutic agents for dermatomyositis through drug-repurposing using public expression datasets. J Invest Dermatol, 2016. PMID: 26975725.
2015
Aran D, Sirota M, Butte AJ. Systematic pan-cancer analysis of tumour purity. Nat Commun. 2015 Dec 4;6:8971. doi: 10.1038/ncomms9971. PMID: 26634437.Chen B, Greenside P, Paik H, Sirota M, Hadley D, Butte AJ. Relating Chemical Structure to Cellular Response: An Integrative Analysis of Gene Expression, Bioactivity, and Structural Data Across 11,000 Compounds. CPT Pharmacometrics Syst Pharmacol, 2015. PMID: 26535158.
Chen B, Sirota M, Fan-Minogue H, Hadley D, Butte AJ. Relating hepatocellular carcinoma tumor samples and cell lines using gene expression data in translational research. BMC Med Genomics, 2015. PMID: 26043652.
Rehm HL, Berg JS, Brooks LD, Bustamante CD, Evans JP, Landrum MJ, Ledbetter DH, Maglott DR, Martin CL, Nussbaum RL, Plon SE, Ramos EM, Sherry ST, Watson MS; ClinGen. ClinGen--the Clinical Genome Resource. N Engl J Med, 2015. PMID: 26014595.
Sirota M, Willemsen G, Sundar P, Pitts SJ, Potluri S, Prifti E, Kennedy S, Ehrlich SD, Neuteboom J, Kluft C, Malone KE, Cox DR, de Geus EJ, Boomsma DI. Effect of genome and environment on metabolic and inflammatory profiles. PLoS One, 2015.PMID: 25853885.
Fan-Minogue H, Chen B, Sikora-Wohlfeld W, Sirota M, Butte AJ. A systematic assessment of linking gene expression with genetic variants for prioritizing candidate targets. Pac Symp Biocomput, 2015. PMID: 25592598.
Wu M, Sirota M, Butte AJ, Chen B. Characteristics of drug combination therapy in oncology by analyzing clinical trial data on ClinicalTrials.gov. Pac Symp Biocomput, 2015.PMID: 25592569.
2014
Palanichamy A*, Apeltsin L*, Kuo TC*, Sirota M*, Wang S, Pitts SJ, Sundar PD, Telman D, Zhao LZ, Derstine M, Abounasr A, Hauser SL, von Büdingen HC. Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis. Sci Transl Med, 2014. PMID: 25100740.von Büdingen HC, Kuo TC, Sirota M, van Belle CJ, Apeltsin L, Glanville J, Cree BA, Gourraud PA, Schwartzburg A, Huerta G, Telman D, Sundar PD, Casey T, Cox DR, Hauser SL. B cell exchange across the blood-brain barrier in multiple sclerosis. J Clin Invest, 2012. PMID: 23160197.
Kodama K, Horikoshi M, Toda K, Yamada S, Hara K, Irie J, Sirota M, Morgan AA, Chen R, Ohtsu H, Maeda S, Kadowaki T, Butte AJ. Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A, 2012. PMID: 22499789.
2012
Khatri P, Sirota M, Butte AJ. Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput Biol, 2012. PMID: 22383865.Liu LY, Schaub MA, Sirota M, Butte AJ. Sex differences in disease risk from reported genome-wide association study findings. Hum Genet, 2012. PMID: 21858542.
Liu LY, Schaub MA, Sirota M, Butte AJ. Transmission distortion in Crohn's disease risk gene ATG16L1 leads to sex difference in disease association. Inflamm Bowel Dis, 2012. PMID: 21618365.
2011
Sirota M*, Dudley JT*, Kim J, Chiang AP, Morgan AA, Sweet-Cordero A, Sage J, Butte AJ. Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med, 2011. PMID: 21849665.Dudley JT*, Sirota M*, Shenoy M, Pai RK, Roedder S, Chiang AP, Morgan AA, Sarwal MM, Pasricha PJ, Butte AJ. Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med, 2011. PMID: 21849664.
Sirota M, Butte AJ. The role of bioinformatics in studying rheumatic and autoimmune disorders. Nat Rev Rheumatol, 2011. PMID: 21691330.
2010
Davydov EV, Goode DL, Sirota M, Cooper GM, Sidow A, Batzoglou S. Identifying a high fraction of the human genome to be under selective constraint using GERP++. PLoS Comput Biol, 2010. PMID: 21152010.Chen R, Davydov EV, Sirota M, Butte AJ. Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association. PLoS One, 2010. PMID: 21042586.
Dudley JT, Schadt E, Sirota M, Butte AJ, Ashley E. Drug discovery in a multidimensional world: systems, patterns, and networks. J Cardiovasc Transl Res, 2010. PMID: 20677029.
2009
Sirota M, Schaub MA, Batzoglou S, Robinson WH, Butte AJ. Autoimmune disease classification by inverse association with SNP alleles. PLoS Genet, 2009. PMID: 20041220.Schaub MA, Kaplow IM, Sirota M, Do CB, Butte AJ, Batzoglou S. A Classifier-based approach to identify genetic similarities between diseases. Bioinformatics, 2009. PMID: 19477990.
2007
Gross SS, Do CB, Sirota M, Batzoglou S. CONTRAST: a discriminative, phylogeny-free approach to multiple informant de novo gene prediction. Genome Biol, 2007. PMID: 18096039.Drosophila 12 Genomes Consortium. Evolution of genes and genomes on the Drosophila phylogeny. Nature, 2007. PMID: 17994087.